Therapeutic strategies against bacterial biofilms
نویسندگان
چکیده
منابع مشابه
Bacterial biofilms: a diagnostic and therapeutic challenge.
Bacteria have traditionally been regarded as individual organisms growing in homogeneous planktonic populations. However, bacteria in natural environments usually form communities of surface-adherent organisms embedded in an extracellular matrix, called biofilms. Current antimicrobial strategies often fail to control bacteria in the biofilm mode of growth. Treatment failure is particularly freq...
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BACKGROUND Chlorhexidine (CHX) is a widely used antimicrobial agent in dentistry. Herein, we report the synthesis of a novel mesoporous silica nanoparticle-encapsulated pure CHX (Nano-CHX), and its mechanical profile and antimicrobial properties against oral biofilms. METHODOLOGY/PRINCIPAL FINDINGS The release of CHX from the Nano-CHX was characterized by UV/visible absorption spectroscopy. T...
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The great clinical significance of biofilm-associated infections and their inherent recalcitrance to antibiotic treatment urgently demand the development of novel antibiofilm strategies. In this regard, antimicrobial peptides (AMPs) are increasingly recognized as a promising template for the development of antibiofilm drugs. Indeed, owing to their main mechanism of action, which relies on the p...
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Microbiologists have extensively worked during the past decade on a particular phase of the bacterial cell cycle known as biofilm, in which single-celled individuals gather together to form a sedentary but dynamic community within a complex structure, displaying spatial and functional heterogeneity. In response to the perception of environmental signals by sensing systems, appropriate responses...
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Biofilm is a multicellular layer of adherent bacteria surrounded by organic polymer matrix. The development of biofilms in food processing environments is a potential source of hazard for food safety and quality [1]. Food contact surfaces are commonly disinfected with different chemical compounds. However, corrosion and toxicity limit the use of these commercial disinfectants [2]. The risk will...
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ژورنال
عنوان ژورنال: Fundamental Research
سال: 2021
ISSN: 2667-3258
DOI: 10.1016/j.fmre.2021.02.003